Phone [Home] 303-456-6187
Phone [Cell] 720-327-4887

WEB:   EMAIL

WEB:   LinkdIn

WEB:   Personal

Residence:   Arvada, Colorado   80005






Lloyd M. Garrick



Summary and interests:

Skilled and Experienced Organic Chemist, Bench or Field Work, Strong Analytical, Instrumentation, Computer Skills.
Research and Development, Process Development, Manufacturing Support.

Biotechnology, Pharmaceuticals, Agriculture, Energy, Mining, Nanotechnology, Fluorine Chemistry, High Energy / Explosives,
Environmental / Natural Resources, Polymers / Materials Science, anything "cutting edge"; novel and new research areas.

Currently [as of 11/2014] employed (contract/temp) doing peptide R&D and Process Development using automated
peptide synthesizers, HPLC/MS,
and wet chemistry as needed.

Concurrently [totally independent and unrelated] also serving as online consultant for an entrepreneurial startup company
{which will remain unnamed} in the areas of hypervalent sulfur - fluorine chemistry.


Qualifications

#   Experienced and competent in all standard organic lab synthesis, workup and analytical techniques.
#   Vacuum Fractional Distillation, Recrystallization, Flash-Column Chromatography and Automated Reverse-Phase HPLC.
#   GC, GC/MS, NMR/NOESY, HPLC, HPLC/MS, IR, DSC
#   Multi-step / large-scale synthesis; Scale-ups from milligram to multigram to kilogram.
#   Small peptides; couplings, isolation, characterization, Small molecule drug discovery and development.
#   Use of [and upkeep, maintenance] Automated Peptide Synthesizers : CSBio, Symphony-X and Tribute instruments from Protein Technologies Inc
#   Analytical Instrument [GC, HPLC, GC/MS] use, maintenance, method development.
#   Lab / Instrument general upkeep, maintenance and use.
#   Experienced with Grignards, Organometallic and Fluorine chemistry.
#   Chemical waste handling and proper disposal, associated paperwork.
#   Process development and production; up to 30-liter scale reactions.
#   Natural products (Taxanes) synthetic modifications and development.
#   Cryogenics (liquid helium – NMR filling)
#   Experienced in the use and handling of hazardous materials such as Phosgene, liquid HCN, HF, Organometallics,
     Organosilicon and Hydride reagents, elemental Fluorine (F2), Fluorination reagents, Strong Nitration Acids, DAST,
     SelectFluor, DeoxyFluor, SbF5, high-oxidation state inorganics.
#   I can synthesize   FLUOLEAD ®   and a variety of   Ar-SF5   compounds for you and your company RIGHT NOW!



Professional Experience

Oct. 2005 – Aug. 2013     UBE America, Inc.     Denver, CO
Research Scientist; Organic Chemist.
#   Organic Synthesis, Research and Process Development. Participated in the development of the novel new
     fluorinating reagent FLUOLEAD ®
.
#   Chief researcher; developed synthetic strategies and processes for novel pentafluorosulfanate (SF5)
     and tetrafluorosulfanyl chloride (SF4Cl) compounds.


May 2004 – July 2005     Tapestry Pharmaceuticals     Boulder, CO
Synthetic Organic Chemist, Process Development.
#   Played a key role in the development of the synthetic procedure for a third generation taxane which is now in clinical trials
     for proliferative disease.
#   Developed alternate synthetic strategies for this taxane compound.

Oct. 2003 – Feb. 2004     FMC Corporation     Princeton, NJ
Process Development Chemist, Agricultural Products.   (contract / temp position).
#   Organic Synthesis and Process Development, Scale ups and Production (15 liter reactions) of agricultural intermediates.
#   Developed significant improvements in the synthetic process for a key agricultural investigational lead compound.

Aug. 1987 – Dec. 2002     Wyeth Research Inc.     Collegeville, PA
Senior Research Chemist.
#   Organic Synthesis. Worked on several diverse projects, including A2/Renin Inhibitors, VnR Inhibitors, Anti-Diabetics,
     PTPase Inhibitors, LHRH Inhibitors.
#   Developed leads, SAR profiles, and ultimately the most active compounds in the PTPase and VnR projects.
#   Developed early lead structure in the A2 Inhibitor project; a derivative thereof went to clinical trials.
#   Discovered and developed the lead structures and SAR profile for compounds in the LHRH project.



Education

M.S. Organic Chemistry     Michigan State University     East Lansing, MI
#   Master of Science degree earned while serving as instructor in undergraduate organic lab courses.
#   Seminars included presentations on novel Grignard reagents and
     the chemistry of poly-nitro aromatic compounds and explosives.

B.S. Chemistry     Purdue University     West Lafayette, IN
#   Bachelor of Science in Chemistry degree obtained while participating in Cooperative Education Work-Study
     program with the DOW Chemical Company, Midland MI.



Patents

#   “Pyrimidocycloalkanes as Angiotensin-II Antagonists” ; U.S. Patent No. 5,234,936 (1993)
#   “Fused Pyrimidines as Angiotensin-II Antagonists” ; U.S. Patent No. 5,236,925 (1993)
#   “Substituted Quinazolines as Angiotensin-II Antagonists” ; U.S. Patent Nos. 5,256,781 , 5,187,168 (1993)
#   “New Acylresorcinol Derivatives as Selective Vitronectin Receptor Inhibitors” ; Intl. Pub. No. W0 99/52879 (1999)
#   “Gonadotropin Releasing Hormone receptor Antagonists” ; 36119.175 US1, AM101799 (2004)



Publications

#   “3-Hydroxy-3-Cyclobutene-1,2-Dione: Application of a Novel Carboxylic Acid Bioisostere to an in-vivo
     Active non-Tetrazole Angiotensin -II Antagonist” ; (Bioorganic and Medicinal Chemistry Letters, 1993)
#   “Synthesis and biological evaluation of piperazinyl heterocyclic antagonists of the gonadotropin releasing hormone
     (GnRH) receptor.” ; Bioorganic & medicinal chemistry letters. 03/2010; 20(8):2512-5.
#   “Small molecule antagonists of the gonadotropin-releasing hormone (GnRH) receptor: structure-activity relationships
     of small heterocyclic groups appended to the 2-phenyl-4-piperazinyl-benzimidazole template.” ;
     Bioorganic & medicinal chemistry letters. 03/2009; 19(7):1986-90.
#   “2-phenyl-4-piperazinylbenzimidazoles: orally active inhibitors of the gonadotropin releasing hormone (GnRH) receptor.” ;
     Bioorganic & medicinal chemistry. 08/2008; 16(13):6617-40.
#   Discovery of practical production processes for arylsulfur pentafluorides and their higher homologues,
     bis- and tris(sulfur pentafluorides): Beginning of a new era of "super-trifluoromethyl" arene chemistry
     and its industry.

     Teruo Umemoto, Lloyd M Garrick, Norimichi Saito
     Beilstein journal of organic chemistry. 01/2012; 8:461-71.


Acknowledged Contributor:

#   “4-Fluoropyrrolidine-2-carbonyl Fluorides: Useful Synthons and Their Facile Preparation with
     4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride” ; J. Org. Chem., 2011, 76 (9), pp 3113-3121
#   “Discovery of 4-tert-Butyl-2,6-dimethylphenylsulfur Trifluoride as a Deoxofluorinating Agent with High Thermal Stability
     as Well as Unusual Resistance to Aqueous Hydrolysis, and Its Diverse Fluorination Capabilities Including Deoxofluoro-Arylsulfinylation
     with High Stereoselectivity” ; J. Am. Chem. Soc., 2010, 132 (51), pp 18199-18205







WebSite by Lloyd Garrick.

All these web sites hand-coded with NotePad and HTML-kit.





Are you interested in research, process development, or manufacturing support for hypervalent sulfur fluoride compounds?
Aromatic SF5 , Perfluorosulfanate , Pentafluorosulfanate , Sulfanyl Pentafluoride , Sulfurpentafluoride , Perfluorosulfanyl , Pentafluorosulfanyl , etc.;
The compounds have many names, and are of the general formula:     Ar-SF5

Only recently available, and at high price for small amounts by inefficient synthesis methods, they have much promising future potential
in many diverse areas such as pharmaceutical, agricultural, bioactive, polymers, dyes, organic semiconductors, liquid crystals, explosives, to name a few.

I spent six years developing the first economically practical production processes for these compounds, as hyperlinked below;
I would like to continue this research, and there are very few other people skilled and knowledgeable in this chemistry.


I have some new research ideas which would not only improve even the existing new process significantly, but would also skirt the existing patents - all I need is a lab!
And the climate (thin cool dry air) in Colorado and nearby states in this part of the country is perfect for this type of work.


Alternatively:

Are you a bio/tech/pharm/med company with entrepreneurial spirit doing novel drug discovery and development?
Or are you looking to develop the next generation of agricultural compounds?
Do you want a serious edge over your competition?
I can make FLUOLEAD ® (the novel new deoxo-fluorinating reagent) and a variety of Aromatic-SF5 building blocks for you right now!
No need to purchase them from current suppliers at rediculous prices!





Aromatic SF5, Perfluorosulfanate, Pentafluorosulfanate, Sulfanyl Pentafluoride, Sulfurpentafluoride, Perfluorosulfanyl, Pentafluorosulfanyl, Lloyd Garrick, explosives, high energy, FLUOLEAD, Aromatic SF5. Perfluorosulfanate. Pentafluorosulfanate. Sulfanyl Pentafluoride. Sulfurpentafluoride. Perfluorosulfanyl. Pentafluorosulfanyl. Lloyd Garrick. explosives. high energy. FLUOLEAD.